Isolated Liver Perfusion
This treatment for liver tumors was first described over thirty
years ago but has had limited clinical use. The basis of this
treatment is to expose the liver to high doses of chemotherapy in
order to achieve maximal tumor shrinkage. The blood supply to the
liver is completely isolated from the systemic circulation so that the
body is not exposed to the high dose of drugs. It requires a lengthy
operation to completely mobilize the liver and to insert catheters
into the hepatic artery, portal vein and hepatic veins.
Recently, initial results using different drugs have been
encouraging and work continues with this modality. This is
experimental therapy and should only be used in a clinical trial.
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